A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cgamma2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

Abe, K., Fuchs, H., Boersma, A., Hans, W., Yu, P., Kalaydjiev, S., Klaften, M., Adler, T., Calzada-Wack, J., Mossbrugger, I., Rathkolb, B., Rozman, J., Prehn, C., Maraslioglu, M., Kametani, Y., Shimada, S., Adamski, J., Busch, D. H., Esposito, I., Klingenspor, M., Wolf, E., Wurst, W., Gailus-Durner, V., Katan, M., Marschall, S., Soewarto, D., Wagner, S., & de Angelis, M. H.

Arthritis Rheum, 63(5): 1301-1311

CD8+ T cell differentiation in the aging immune system: until the last clone standing

Buchholz, V. R., Neuenhahn, M., & Busch, D. H.

Curr Opin Immunol, 23(4): 549-554

TNF receptor I on human keratinocytes is a binding partner for staphylococcal protein A resulting in the activation of NF kappa B, AP-1, and downstream gene transcription

Classen, A., Kalali, B. N., Schnopp, C., Andres, C., Aguilar-Pimentel, J. A., Ring, J., Ollert, M., & Mempel, M.

Exp Dermatol, 20(1): 48-52

Cytokine reporter mice in immunological research: perspectives and lessons learned

Croxford, A. L., & Buch, T.

Immunology, 132(1): 1-8

Mouse phenotyping

Fuchs, H., Gailus-Durner, V., Adler, T., Aguilar-Pimentel, J. A., Becker, L., Calzada-Wack, J., Da Silva-Buttkus, P., Neff, F., Gotz, A., Hans, W., Holter, S. M., Horsch, M., Kastenmuller, G., Kemter, E., Lengger, C., Maier, H., Matloka, M., Moller, G., Naton, B., Prehn, C., Puk, O., Racz, I., Rathkolb, B., Romisch-Margl, W., Rozman, J., Wang-Sattler, R., Schrewe, A., Stoger, C., Tost, M., Adamski, J., Aigner, B., Beckers, J., Behrendt, H., Busch, D. H., Esposito, I., Graw, J., Illig, T., Ivandic, B., Klingenspor, M., Klopstock, T., Kremmer, E., Mempel, M., Neschen, S., Ollert, M., Schulz, H., Suhre, K., Wolf, E., Wurst, W., Zimmer, A., & Hrabe de Angelis, M.

Methods, 53(2): 120-135

Antibiotic prophylaxis in primary and revision hip arthroplasty : What is the evidence?

Gradl, G., Horn, C., Postl, L. K.., Miethke, T., & Gollwitzer, H.

Orthopade, 40(6): 520-527

Cord blood Valpha24-vbeta11 natural killer T cells display a Th2-chemokine receptor profile and cytokine responses

Harner, S., Noessner, E., Nadas, K., Leumann-Runge, A., Schiemann, M., Faber, F. L., Heinrich, J., & Krauss-Etschmann, S.

PLoS ONE, 6(1): e15714

Inflammation: cell recruitment versus local proliferation

Helming, L.

Curr Biol, 21(14): R548-550

The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release

Hoegen, T., Tremel, N., Klein, M., Angele, B., Wagner, H., Kirschning, C., Pfister, H. W., Fontana, A., Hammerschmidt, S., and Koedel, U.

J Immunol 187, 5440-5451

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

Horsch, M., Seeburg, P. H., Adler, T., Aguilar-Pimentel, J. A., Becker, L., Calzada-Wack, J., Garrett, L., Gotz, A., Hans, W., Higuchi, M., Holter, S. M., Naton, B., Prehn, C., Puk, O., Racz, I., Rathkolb, B., Rozman, J., Schrewe, A., Adamski, J., Busch, D. H., Esposito, I., Graw, J., Ivandic, B., Klingenspor, M., Klopstock, T., Mempel, M., Ollert, M., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Gailus-Durner, V., Fuchs, H., de Angelis, M. H., and Beckers, J.

J Biol Chem 286, 18614-18622

Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells

Istvanffy, R., Kroger, M., Eckl, C., Gitzelmann, S., Vilne, B., Bock, F., Graf, S., Schiemann, M., Keller, U. B., Peschel, C., & Oostendorp, R. A.

Blood, 118(10): 2712-2722

Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction

Kastenmuller, W., Gasteiger, G., Subramanian, N., Sparwasser, T., Busch, D. H., Belkaid, Y., Drexler, I., & Germain, R. N.

J Immunol, 187(6): 3186-3197

The IFN-gamma-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

Liesenfeld, O., Parvanova, I., Zerrahn, J., Han, S. J., Heinrich, F., Munoz, M., Kaiser, F., Aebischer, T., Buch, T., Waisman, A., Reichmann, G., Utermohlen, O., von Stebut, E., von Loewenich, F. D., Bogdan, C., Specht, S., Saeftel, M., Hoerauf, A., Mota, M. M., Konen-Waisman, S., Kaufmann, S. H., & Howard, J. C.

PLoS ONE, 6(6): e20568

Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain

Luckerath, K., Kirkin, V., Melzer, I. M., Thalheimer, F. B., Siele, D., Milani, W., Adler, T., Aguilar-Pimentel, A., Horsch, M., Michel, G., Beckers, J., Busch, D. H., Ollert, M., Gailus-Durner, V., Fuchs, H., Hrabe de Angelis, M., Staal, F. J., Rajalingam, K., Hueber, A. O., Strobl, L. J., Zimber-Strobl, U., & Zornig, M.

Blood, 117(2): 519-529

Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes

Luque, R. M., Lin, Q., Cordoba-Chacon, J., Subbaiah, P. V., Buch, T., Waisman, A., Vankelecom, H., & Kineman, R. D.

PLoS ONE, 6(1): e15767

Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45- cells

Mackern-Oberti, J. P., Breser, M. L., Nunez, N., Maccioni, M., Rodriguez, N., Wantia, N., Ertl, T., Miethke, T., & Rivero, V. E.

Reproduction 2011 Sep;142(3):427-37. Epub 2011 Jul 5

Innate immunity in the male genital tract: Chlamydia trachomatis induces keratinocyte-derived chemokine production in prostate, seminal vesicle and epididymis/vas deferens primary cultures

Mackern-Oberti, J. P., Maccioni, M., Breser, M. L., Eley, A., Miethke, T., & Rivero, V. E.

J Med Microbiol, 60(Pt 3): 307-316

Increasing Therapeutic Challenges through Multi-Resistant Bacteria in the Hospital

Miethke, T.

Zentralbl Chir.

A comprehensive analysis of the COL29A1 gene does not support a role in eczema

Naumann, A., Soderhall, C., Folster-Holst, R., Baurecht, H., Harde, V., Muller-Wehling, K., Rodriguez, E., Ruether, A., Franke, A., Wagenpfeil, S., Novak, N., Mempel, M., Kalali, B. N., Allgaeuer, M., Koch, J., Gerhard, M., Melen, E., Wahlgren, C. F., Kull, I., Stahl, C., Pershagen, G., Lauener, R., Riedler, J., Doekes, G., Scheynius, A., Illig, T., von Mutius, E., Schreiber, S., Kere, J., Kabesch, M., & Weidinger, S.

Allergy Clin Immunol, 127(5): 1187-1194 e1187

Primary extrahepatic alveolar echinococcosis of the lumbar spine and the psoas muscle

Nell, M., Burgkart, R. H., Gradl, G., von Eisenhart-Rothe, R., Schaeffeler, C., Trappe, D., da Costa, C. P., Gradinger, R., & Kirchhoff, C.

Ann Clin Microbiol Antimicrob, 10:13

SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer

Neumann, J., Bahr, F., Horst, D., Kriegl, L., Engel, J., Mejias Luque, R., Gerhard, M., Kirchner, T., and Jung, A.

BMC Cancer 11, 518

Toxicity modeling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

Raab, M., Kappel, S., Kramer, A., Sanhaji, M., Matthess, Y., Kurunci-Csacsko, E., Calzada-Wack, J., Rathkolb, B., Rozman, J., Adler, T., Busch, D. H., Esposito, I., Fuchs, H., Gailus-Durner, V., Klingenspor, M., Wolf, E., Sanger, N., Prinz, F., Angelis, M. H., Seibler, J., Yuan, J., Bergmann, M., Knecht, R., Kreft, B., and Strebhardt, K.

Nat Commun 2, 395

Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response

Reim, D., Rossmann-Bloeck, T., Jusek, G., Prazeres da Costa, O., & Holzmann, B.

J Leukoc Biol. 2011 Sep;90(3):613-20

Invasion and destruction of a murine fibrosarcoma by Salmonella-induced effector CD8 T cells as a therapeutic intervention against cancer

Roider, E., Jellbauer, S., Kohn, B., Berchtold, C., Partilla, M., Busch, D. H., Russmann, H., & Panthel, K.

Cancer Immunol Immunother, 60(3): 371-380

Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs.

Schlitzer, A., Loschko, J., Mair, K., Vogelmann, R., Henkel, L., Einwachter, H., Schiemann, M., Niess, J. H., Reindl, W., & Krug, A.

Blood, 117(24): 6562-6570

Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation

Schmitt, A., Tonn, T., Busch, D. H., Grigoleit, G. U., Einsele, H., Odendahl, M., Germeroth, L., Ringhoffer, M., Ringhoffer, S., Wiesneth, M., Greiner, J., Michel, D., Mertens, T., Rojewski, M., Marx, M., von Harsdorf, S., Dohner, H., Seifried, E., Bunjes, D., & Schmitt, M.

Transfusion, 51(3): 591-599

Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis

Schwandt, T., Schumak, B., Gielen, G. H., Jungerkes, F., Schmidbauer, P., Klocke, K., Staratschek-Jox, A., van Rooijen, N., Kraal, G., Ludwig-Portugall, I., Franken, L., Wehner, S., Kalff, J. C., Weber, O., Kirschning, C., Coch, C., Kalinke, U., Wenzel, J., Kurts, C., Zawatzky, R., Holzmann, B., Layland, L., Schultze, J. L., Burgdorf, S., den Haan, J. M., Knolle, P. A., & Limmer, A.

EMBO J. 2011 Oct 28;31(1):201-13

Different capacity of monocyte subsets to phagocytose iron-oxide nanoparticles

Settles, M., Etzrodt, M., Kosanke, K., Schiemann, M., Zimmermann, A., Meier, R., Braren, R., Huber, A., Rummeny, E. J., Weissleder, R., Swirski, F. K., & Wildgruber, M.

PLoS ONE, 6(10): e25197

CCL17 controls mast cells for the defense against filarial larval entry

Specht, S., Frank, J. K., Alferink, J., Dubben, B., Layland, L. E., Denece, G., Bain, O., Forster, I., Kirschning, C. J., Martin, C., & Hoerauf, A.

J Immunol, 186(8): 4845-4852

Specific recognition and inhibition of Ewing tumor growth by antigen-specific allo-restricted cytotoxic T cells

Thiel, U., Pirson, S., Muller-Spahn, C., Conrad, H., Busch, D. H., Bernhard, H., Burdach, S., & Richter, G. H.

Br J Cancer, 104(6): 948-95

Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

Toller, I. M., Neelsen, K. J., Steger, M., Hartung, M. L., Hottiger, M. O., Stucki, M., Kalali, B., Gerhard, M., Sartori, A. A., Lopes, M., & Muller, A.

Proc Natl Acad Sci U S A, 108(36): 14944-14949

A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha(+) dendritic cells depends on glycoprotein GPIb and complement C3

Verschoor, A., Neuenhahn, M., Navarini, A. A., Graef, P., Plaumann, A., Seidlmeier, A., Nieswandt, B., Massberg, S., Zinkernagel, R. M., Hengartner, H., and Busch, D. H.

Nat Immunol 12, 1194-1201

New vistas on TLR9 activation

Wagner, H.

Eur J Immunol 41, 2814-2816

Toll-Like Receptors 2 and 4 Regulate the Frequency of IFN?Producing CD4 T-Cells during Pulmonary Infection with Chlamydia pneumoniae

Wantia N, Rodriguez N, Cirl C, Ertl T, Dürr S, Layland LE, Wagner H, Miethke T

PLoS ONE 6, e26101

Genetic variants of toll-like receptor 2 and 5, helicobacter pylori infection, and risk of gastric cancer and its precursors in a chinese population

Gerhard, M., Classen, M., and You, W. C.

Cancer Epidemiol Biomarkers Prev 20, 2594-2602