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Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice.
Vaccine 34: 923-932.
Beil-Wagner, J., G. Dossinger, K. Schober, J. Vom Berg, A. Tresch, M. Grandl, P. Palle, F. Mair, M. Gerhard, B. Becher, D. H. Busch, and T. Buch. (2016)
T cell-specific inactivation of mouse CD2 by CRISPR/Cas9.
Sci Rep 6: 21377.
Berger, E., E. Rath, D. Yuan, N. Waldschmitt, S. Khaloian, M. Allgauer, O. Staszewski, E.M. Lobner, T. Schottl, P. Giesbertz, O.I. Coleman, M. Prinz, A. Weber, M. Gerhard, M. Klingenspor, K.P. Janssen, M. Heikenwalder, and D. Haller. (2016)
Mitochondrial function controls intestinal epithelial stemness and proliferation.
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Bhattacharjee, S., N. Kalbfuss, and C. Prazeres da Costa. (2016)
Parasites, microbiota and metabolic disease.
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Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo.
Oncotarget. 7:43267-43280.
Bolz, C., N.C. Bach, H. Meyer, G. Muller, M. Dawidowski, G. Popowicz, S.A. Sieber, A. Skerra, and M. Gerhard. (2016)
Comparison of enzymatic properties and small molecule inhibition of gamma-glutamyltranspeptidases from pathogenic and commensal bacteria.
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Broadley, S.P., A. Plaumann, R. Coletti, C. Lehmann, A. Wanisch, A. Seidlmeier, K. Esser, S. Luo, P.C. Ramer, S. Massberg, D.H. Busch, M. van Lookeren Campagne, and A. Verschoor. (2016)
Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity.
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T Cell Fate at the Single-Cell Level.
Annual review of immunology 34: 65-92.
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Role of memory T cell subsets for adoptive immunotherapy.
Seminars in immunology 28: 28-34.
Chachage, M., G. Pollakis, E.O. Kuffour, K. Haase, A. Bauer, Y. Nadai, L. Podola, P. Clowes, M. Schiemann, L. Henkel, D. Hoffmann, S. Joseph, S. Bhuju, L. Maboko, F.S. Sarfo, K. Eberhardt, M. Hoelscher, T. Feldt, E. Saathoff, and C. Geldmacher. (2016)
CD25+ FoxP3+ Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo.
J Virol. 90:8954-8967.
Come, C., A. Cvrljevic, M. M. Khan, I. Treise, T. Adler, J. A. Aguilar-Pimentel, B. Au-Yeung, E. Sittig, T. D. Laajala, Y. Chen, S. Oeder, J. Calzada-Wack, M. Horsch, T. Aittokallio, D. H. Busch, M. W. Ollert, F. Neff, J. Beckers, V. Gailus-Durner, H. Fuchs, M. Hrabe de Angelis, Z. Chen, R. Lahesmaa, and J. Westermarck. (2016)
CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection.
PloS one 11: e0152996.
Eden, M., B. Meder, M. Volkers, M. Poomvanicha, K. Domes, M. Branchereau, P. Marck, R. Will, A. Bernt, A. Rangrez, M. Busch, C. German Mouse Clinic, M. Hrabe de Angelis, C. Heymes, W. Rottbauer, P. Most, F. Hofmann, and N. Frey. (2016)
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
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Fuchs, H., S. Sabrautzki, G.K. Przemeck, S. Leuchtenberger, B. Lorenz-Depiereux, L. Becker, B. Rathkolb, M. Horsch, L. Garrett, M.A. Ostereicher, W. Hans, K. Abe, N. Sagawa, J. Rozman, I.L. Vargas-Panesso, M. Sandholzer, T.S. Lisse, T. Adler, J.A. Aguilar-Pimentel, J. Calzada-Wack, N. Ehrhard, R. Elvert, C. Gau, S.M. Holter, K. Micklich, K. Moreth, C. Prehn, O. Puk, I. Racz, C. Stoeger, A. Vernaleken, D. Michel, S. Diener, T. Wieland, J. Adamski, R. Bekeredjian, D.H. Busch, J. Favor, J. Graw, M. Klingenspor, C. Lengger, H. Maier, F. Neff, M. Ollert, T. Stoeger, A.O. Yildirim, T.M. Strom, A. Zimmer, E. Wolf, W. Wurst, T. Klopstock, J. Beckers, V. Gailus-Durner, and M. Hrabe de Angelis. (2016)
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
G3 (Bethesda). 6:4035-4046.
Javaheri, A., T. Kruse, K. Moonens, R. Mejias-Luque, A. Debraekeleer, C.I. Asche, N. Tegtmeyer, B. Kalali, N.C. Bach, S.A. Sieber, D.J. Hill, V. Koniger, C.R. Hauck, R. Moskalenko, R. Haas, D.H. Busch, E. Klaile, H. Slevogt, A. Schmidt, S. Backert, H. Remaut, B.B. Singer, and M. Gerhard. (2016)
Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.
Nat Microbiol. 2:16189.
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Multicentre investigation of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in German hospitals.
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Helicobacter pylori gamma-Glutamyltranspeptidase Induces Tolerogenic Human Dendritic Cells by Activation of Glutamate Receptors.
J Immunol. 196:4246-4252.
Kirschner, A., M. Thiede, F. Blaeschke, G.H. Richter, J.S. Gerke, M.C. Baldauf, T.G. Grunewald, D.H. Busch, S. Burdach, and U. Thiel. (2016)
Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens.
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Kumar, S., B. Rathkolb, E. Kemter, S. Sabrautzki, D. Michel, T. Adler, L. Becker, J. Beckers, D. H. Busch, L. Garrett, W. Hans, S. M. Holter, M. Horsch, M. Klingenspor, T. Klopstock, I. Racz, J. Rozman, I. L. Vargas Panesso, A. Vernaleken, A. Zimmer, H. Fuchs, V. Gailus-Durner, M. Hrabe de Angelis, E. Wolf, and B. Aigner. (2016)
Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice.
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An Unusual Presentation of Neurocysticercosis: A Space-Occupying Lesion in the Fourth Ventricle Associated with Progressive Cognitive Decline.
The American journal of tropical medicine and hygiene 94: 172-175.
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Comparison of 1,3-beta-d-glucan with galactomannan in serum and bronchoalveolar fluid for the detection of Aspergillus species in immunosuppressed mechanical ventilated critically ill patients.
J Crit Care. 36:259-264.
Muschaweckh, A., V.R. Buchholz, A. Fellenzer, C. Hessel, P.A. Konig, S. Tao, R. Tao, M. Heikenwalder, D.H. Busch, T. Korn, W. Kastenmuller, I. Drexler, and G. Gasteiger. (2016)
Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells.
J Exp Med. 213:3075-3086.
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Flow cytometry-based TCR-ligand Koff -rate assay for fast avidity screening of even very small antigen-specific T cell populations ex vivo.
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Dysregulation of proinflammatory versus anti-inflammatory human TH17 cell functionalities in the autoinflammatory Schnitzler syndrome.
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Oduro, J.D., A. Redeker, N.A. Lemmermann, L. Ebermann, T.F. Marandu, I. Dekhtiarenko, J.K. Holzki, D.H. Busch, R. Arens, and L. Cicin-Sain. (2016)
Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection.
J Gen Virol. 97:185-195.
Pan, K. F., L. Zhang, M. Gerhard, J. L. Ma, W. D. Liu, K. Ulm, J. X. Wang, L. Zhang, Y. Zhang, M. Bajbouj, L. F. Zhang, M. Li, M. Vieth, R. Y. Liu, M. Quante, L. H. Wang, S. Suchanek, T. Zhou, W. X. Guan, R. Schmid, M. Classen, and W. C. You. (2016)
A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication.
Gut 65: 9-18.
Paszkiewicz, P.J., S.P. Frassle, S. Srivastava, D. Sommermeyer, M. Hudecek, I. Drexler, M. Sadelain, L. Liu, M.C. Jensen, S.R. Riddell, and D.H. Busch. (2016)
Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia.
J Clin Invest. 126:4262-4272.
Penkert, H., Delbridge, C., Wantia, N., Wiestler, B., and Korn, T. (2016)
Fulminant Central Nervous System Nocardiosis in a Patient Treated With Alemtuzumab for Relapsing-Remitting Multiple Sclerosis.
JAMA Neurol 73, 757-759.
Platteel, A. C., M. Mishto, K. Textoris-Taube, C. Keller, J. Liepe, D. H. Busch, P. M. Kloetzel, and A. J. Sijts. (2016)
CD8(+) T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products.
European journal of immunology 46: 1109-1118.
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Next-generation TCR sequencing - a tool to understand T-cell infiltration in human cancers.
J Pathol. 240:384-386.
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Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.
Cell Rep. 17:2572-2583.
Schirmer, D., T.G. Grunewald, R. Klar, O. Schmidt, D. Wohlleber, R.A. Rubio, W. Uckert, U. Thiel, F. Bohne, D.H. Busch, A.M. Krackhardt, S. Burdach, and G.H. Richter. (2016)
Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.
Oncoimmunology. 5:e1175795.
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A synergistic combination: using RNAseq to decipher both T-cell receptor sequence and transcriptional profile of individual T cells.
Immunol Cell Biol. 94:529-530.
Schober, K., and D.H. Busch. (2016)
TIL 2.0: More effective and predictive T-cell products by enrichment for defined antigen specificities.
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Increased choline uptake in macrophages and prostate cancer cells does not allow for differentiation between benign and malignant prostate pathologies.
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Microbes and asthma: Opportunities for intervention.
J Allergy Clin Immunol. 137:690-697.
Tagawa, T., Albanese, M., Bouvet, M., Moosmann, A., Mautner, J., Heissmeyer, V., Zielinski, C., Lutter, D., Hoser, J., Hastreiter, M., et al. (2016)
Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing.
J Exp Med 213, 2065-2080.
Tegtmeyer, N., Y. Moodley, Y. Yamaoka, S. R. Pernitzsch, V. Schmidt, F. R. Traverso, T. P. Schmidt, R. Rad, K. G. Yeoh, H. Bow, J. Torres, M. Gerhard, G. Schneider, S. Wessler, and S. Backert. (2016)
Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA.
Molecular microbiology 99: 925-944.
Telieps, T., M. Kohler, I. Treise, K. Foertsch, T. Adler, D. H. Busch, M. Hrabe de Angelis, A. Verschoor, K. Adler, E. Bonifacio, and A. G. Ziegler. (2016)
Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice.
Journal of diabetes research 2016: 4208156.
Textor, A., K. Schmidt, P.M. Kloetzel, B. Weissbrich, C. Perez, J. Charo, K. Anders, J. Sidney, A. Sette, T.N. Schumacher, C. Keller, D.H. Busch, U. Seifert, and T. Blankenstein. (2016)
Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.
J Exp Med. 213:2333-2348.
Tunger, A., R. Wehner, M. von Bonin, D. Kuhn, F. Heidenreich, S. Matko, M. Nauerth, E. Rucker-Braun, S. Dietz, C.S. Link, A. Eugster, M. Odendahl, D.H. Busch, T. Tonn, E. Bonifacio, L. Germeroth, J. Schetelig, M.P. Bachmann, M. Bornhauser, and M. Schmitz. (2016)
Generation of high-avidity, WT1-reactive CD8+ cytotoxic T cell clones with anti-leukemic activity by streptamer technology.
Leuk Lymphoma:1-4.
Velin, D., K. Straubinger, and M. Gerhard. (2016)
Inflammation, immunity, and vaccines for Helicobacter pylori infection.
Helicobacter. 21 Suppl 1:26-29.
Waldhuber, A., M. Puthia, A. Wieser, C. Cirl, S. Dürr, F. Römmler, T. Müller, S. Schubert, O. Groß, C. Svanborg, T. Miethke. (2016)
Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation.
J Clin Invest. 2016;126(7):2425-2436
Wildgruber, M., T. Aschenbrenner, H. Wendorff, M. Czubba, A. Glinzer, B. Haller, M. Schiemann, A. Zimmermann, H. Berger, H.H. Eckstein, R. Meier, W.A. Wohlgemuth, P. Libby, and A. Zernecke. (2016)
The "Intermediate" CD14++CD16+ monocyte subset increases in severe peripheral artery disease in humans.
Sci Rep. 6:39483.
Wildgruber, M., M. Czubba, T. Aschenbrenner, H. Wendorff, A. Hapfelmeier, A. Glinzer, M. Schiemann, A. Zimmermann, H.H. Eckstein, H. Berger, W.A. Wohlgemuth, R. Meier, P. Libby, and A. Zernecke. (2016)
Increased intermediate CD14++CD16++ monocyte subset levels associate with restenosis after peripheral percutaneous transluminal angioplasty.
Atherosclerosis. 253:128-134.
Zhong, Y., F. Anderl, T. Kruse, F. Schindele, E.K. Jagusztyn-Krynicka, W. Fischer, M. Gerhard, and R. Mejias-Luque. (2016)
Helicobacter pylori HP0231 Influences Bacterial Virulence and Is Essential for Gastric Colonization.
PLoS One. 11:e0154643.