Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis

Abdul-Sater, A. A., Koo, E., Hacker, G. and Ojcius, D. M.

J Biol Chem 2009. 284: 26789-26796

Specific CD8 T Cells in Ige-mediated Allergy Correlate with Allergen Dose and Allergic Phenotype

Aguilar-Pimentel, J. A., Alessandrini, F., Huster, K. M., Jakob, T., Schulz, H., Behrendt, H., Ring, J., Hrabe de Angelis, M., Busch, D. H., Mempel, M. and Ollert, M.

Am J Respir Crit Care Med 2009

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guerin

Andersen, C. A., Rosenkrands, I., Olsen, A. W., Nordly, P., Christensen, D., Lang, R., Kirschning, C., Gomes, J. M., Bhowruth, V., Minnikin, D. E., Besra, G. S., Follmann, F., Andersen, P. and Agger, E. M.

J Immunol 2009. 183: 2294-2302

Impaired antibody response causes persistence of prototypic T cell-contained virusPLoS

Bergthaler, A., Flatz, L., Verschoor, A., Hegazy, A. N., Holdener, M., Fink, K., Eschli, B., Merkler, D., Sommerstein, R., Horvath, E., Fernandez, M., Fitsche, A., Senn, B. M., Verbeek, J. S., Odermatt, B., Siegrist, C. A. and Pinschewer, D. D.

Biol 2009. 7: e1000080

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells

Besch, R., Poeck, H., Hohenauer, T., Senft, D., Hacker, G., Berking, C., Hornung, V., Endres, S., Ruzicka, T., Rothenfusser, S. and Hartmann, G.

J Clin Invest 2009. 119: 2399-2411

Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells

Brenk, M., Scheler, M., Koch, S., Neumann, J., Takikawa, O., Hacker, G., Bieber, T. and von Bubnoff, D.

J Immunol 2009. 183: 145-154

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

Enard, W., Gehre, S., Hammerschmidt, K., Holter, S. M., Blass, T., Somel, M., Bruckner, M. K., Schreiweis, C., Winter, C., Sohr, R., Becker, L., Wiebe, V., Nickel, B., Giger, T., Muller, U., Groszer, M., Adler, T., Aguilar, A., Bolle, I., Calzada-Wack, J., Dalke, C., Ehrhardt, N., Favor, J., Fuchs, H., Gailus-Durner, V., Hans, W., Holzlwimmer, G., Javaheri, A., Kalaydjiev, S., Kallnik, M., Kling, E., Kunder, S., Mossbrugger, I., Naton, B., Racz, I., Rathkolb, B., Rozman, J., Schrewe, A., Busch, D. H., Graw, J., Ivandic, B., Klingenspor, M., Klopstock, T., Ollert, M., Quintanilla-Martinez, L., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Fisher, S. E., Morgenstern, R., Arendt, T., de Angelis, M. H., Fischer, J., Schwarz, J. and Paabo, S.

Cell 2009. 137: 961-971

Experimental models of acute infection and Toll-like receptor driven septic shock

Ferstl, R., Spiller, S., Fichte, S., Dreher, S. and Kirschning, C. J.

Methods Mol Biol 2009. 517: 313-327

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models

Fuchs, H., Gailus-Durner, V., Adler, T., Pimentel, J. A., Becker, L., Bolle, I., Brielmeier, M., Calzada-Wack, J., Dalke, C., Ehrhardt, N., Fasnacht, N., Ferwagner, B., Frischmann, U., Hans, W., Holter, S. M., Holzlwimmer, G., Horsch, M., Javaheri, A., Kallnik, M., Kling, E., Lengger, C., Maier, H., Mossbrugger, I., Morth, C., Naton, B., Noth, U., Pasche, B., Prehn, C., Przemeck, G., Puk, O., Racz, I., Rathkolb, B., Rozman, J., Schable, K., Schreiner, R., Schrewe, A., Sina, C., Steinkamp, R., Thiele, F., Willershauser, M., Zeh, R., Adamski, J., Busch, D. H., Beckers, J., Behrendt, H., Daniel, H., Esposito, I., Favor, J., Graw, J., Heldmaier, G., Hofler, H., Ivandic, B., Katus, H., Klingenspor, M., Klopstock, T., Lengeling, A., Mempel, M., Muller, W., Neschen, S., Ollert, M., Quintanilla-Martinez, L., Rosenstiel, P., Schmidt, J., Schreiber, S., Schughart, K., Schulz, H., Wolf, E., Wurst, W., Zimmer, A. and Hrabe de Angelis, M.

Curr Pharm Biotechnol 2009. 10: 236-243

Systemic first-line phenotyping

Gailus-Durner, V., Fuchs, H., Adler, T., Aguilar Pimentel, A., Becker, L., Bolle, I., Calzada-Wack, J., Dalke, C., Ehrhardt, N., Ferwagner, B., Hans, W., Holter, S. M., Holzlwimmer, G., Horsch, M., Javaheri, A., Kallnik, M., Kling, E., Lengger, C., Morth, C., Mossbrugger, I., Naton, B., Prehn, C., Puk, O., Rathkolb, B., Rozman, J., Schrewe, A., Thiele, F., Adamski, J., Aigner, B., Behrendt, H., Busch, D. H., Favor, J., Graw, J., Heldmaier, G., Ivandic, B., Katus, H., Klingenspor, M., Klopstock, T., Kremmer, E., Ollert, M., Quintanilla-Martinez, L., Schulz, H., Wolf, E., Wurst, W. and de Angelis, M. H.

Methods Mol Biol 2009. 530: 463-509

High hydrostatic pressure for disinfection of bone grafts and biomaterials: an experimental study

Gollwitzer, H., Mittelmeier, W., Brendle, M., Weber, P., Miethke, T., Hofmann, G. O., Gerdesmeyer, L., Schauwecker, J. and Diehl, P.

Open Orthop J 2009. 3: 1-7

Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function

Grzmil, P., Konietzko, J., Boehm, D., Holter, S. M., Aguilar-Pimentel, A., Javaheri, A., Kalaydjiev, S., Adler, T., Bolle, I., Adham, I., Dixkens, C., Wolf, S., Fuchs, H., Gailus-Durner, V., Wurst, W., Ollert, M., Busch, D. H., Schulz, H., de Angelis, M. H. and Burfeind, P.

Cytogenet Genome Res 2009. 125: 186-200

Sequence independent interferon-alpha induction by multimerized phosphodiester DNA depends on spatial regulation of Toll-like receptor-9 activation in plasmacytoid dendritic cells

Haas, T., Schmitz, F., Heit, A. and Wagner, H.

Immunology 2009. 126: 290-298

The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress

Heermann, R., Weber, A., Mayer, B., Ott, M., Hauser, E., Gabriel, G., Pirch, T. and Jung, K.

J Mol Biol 2009. 386: 134-148

Molecular mediators of macrophage fusion. Trends Cell

Helming, L. and Gordon, S.

Biol 2009. 19: 514-522

The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion

Helming, L., Winter, J. and Gordon, S.

J Cell Sci 2009. 122: 453-459

Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax

Hippe, D., Weber, A., Zhou, L., Chang, D. C., Hacker, G. and Luder, C. G.

J Cell Sci 2009. 122: 3511-3521

Cutting edge: memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function

Huster, K. M., Stemberger, C., Gasteiger, G., Kastenmuller, W., Drexler, I. and Busch, D. H.

J Immunol 2009. 183: 6898-6902

Effectiveness of ozone against endodontopathogenic microorganisms in a root canal biofilm model

Huth, K. C., Quirling, M., Maier, S., Kamereck, K., Alkhayer, M., Paschos, E., Welsch, U., Miethke, T., Brand, K. and Hickel, R.

Int Endod J 2009. 42: 3-13

Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice

Isensee, J., Meoli, L., Zazzu, V., Nabzdyk, C., Witt, H., Soewarto, D., Effertz, K., Fuchs, H., Gailus-Durner, V., Busch, D., Adler, T., de Angelis, M. H., Irgang, M., Otto, C. and Noppinger, P. R.

Endocrinology 2009. 150: 1722-1730

Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens

Kastenmuller, W., Gasteiger, G., Stross, L., Busch, D. H. and Drexler, I.

J Immunol 2009. 182: 2573-2577

Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis

Koedel, U., Frankenberg, T., Kirschnek, S., Obermaier, B., Hacker, H., Paul, R. and Hacker, G.

PLoS Pathog 2009. 5: e1000461

Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk

Kormann, M. S., Ferstl, R., Depner, M., Klopp, N., Spiller, S., Illig, T., Vogelberg, C., von Mutius, E., Kirschning, C. J. and Kabesch, M.

Allergy 2009. 64: 636-642

Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY-ESO-1 have potent anti-tumor activity

Kronig, H., Hofer, K., Conrad, H., Guilaume, P., Muller, J., Schiemann, M., Lennerz, V., Cosma, A., Peschel, C., Busch, D. H., Romero, P. and Bernhard, H.

Int J Cancer 2009. 125: 649-655

 Hematopoietic cell-derived interferon controls viral replication and virus-induced disease

Lang, P. A., Cervantes-Barragan, L., Verschoor, A., Navarini, A. A., Recher, M., Pellegrini, M., Flatz, L., Bergthaler, A., Honda, K., Ludewig, B., Ohashi, P. S. and Lang, K. S.

Blood 2009. 113: 1045-1052

Induction of tumor cell apoptosis or necrosis by conditional expression of cell death proteins: analysis of cell death pathways and in vitro immune stimulatory potential

Lohmann, C., Muschaweckh, A., Kirschnek, S., Jennen, L., Wagner, H. and Hacker, G.

J Immunol 2009. 182: 4538-4546

Mycoplasma contamination of murine embryonic stem cells affects cell parameters, germline transmission and chimeric progeny

Markoullis, K., Bulian, D., Holzlwimmer, G., Quintanilla-Martinez, L., Heiliger, K. J., Zitzelsberger, H., Scherb, H., Mysliwietz, J., Uphoff, C. C., Drexler, H. G., Adler, T., Busch, D. H., Schmidt, J. and Mahabir, E.

Transgenic Res 2009. 18: 71-87

Alternative activation of macrophages: an immunologic functional perspective

Martinez, F. O., Helming, L. and Gordon, S.

Annu Rev Immunol 2009. 27: 451-483

Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors

Moretti, A., Bellin, M., Jung, C. B., Thies, T. M., Takashima, Y., Bernshausen, A., Schiemann, M., Fischer, S., Moosmang, S., Smith, A. G., Lam, J. T. and Laugwitz, K. L.

FASEB J 2009

Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections

Navarini, A. A., Lang, K. S., Verschoor, A., Recher, M., Zinkernagel, A. S., Nizet, V., Odermatt, B., Hengartner, H. and Zinkernagel, R. M.

Proc Natl Acad Sci U S A 2009. 106: 7107-7112

Development of novel implant abutments using the shape memory alloy nitinol: preliminary results

Pautke, C., Kolk, A., Brokate, M., Wehrstedt, J. C., Kneissl, F., Miethke, T., Steinhauser, E., Horch, H. H. and Deppe, H.

Int J Oral Maxillofac Implants 2009. 24: 477-483

Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori

Rad, R., Ballhorn, W., Voland, P., Eisenacher, K., Mages, J., Rad, L., Ferstl, R., Lang, R., Wagner, H., Schmid, R. M., Bauer, S., Prinz, C., Kirschning, C. J. and Krug, A.

Gastroenterology 2009 136: 2247-2257

Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells

Renstrom, J., Istvanffy, R., Gauthier, K., Shimono, A., Mages, J., Jardon-Alvarez, A., Kroger, M., Schiemann, M., Busch, D. H., Esposito, I., Lang, R., Peschel, C. and Oostendorp, R. A.

Cell Stem Cell 2009. 5: 157-167

Conduits mediate transport of low-molecular-weight antigen to lymph node follicles

Roozendaal, R., Mempel, T. R., Pitcher, L. A., Gonzalez, S. F., Verschoor, A., Mebius, R. E., von Andrian, U. H. and Carroll, M. C.

Immunity 2009. 30: 264-276

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

Rubio-Aliaga, I., Przemeck, G. K., Fuchs, H., Gailus-Durner, V., Adler, T., Hans, W., Horsch, M., Rathkolb, B., Rozman, J., Schrewe, A., Wagner, S., Hoelter, S. M., Becker, L., Klopstock, T., Wurst, W., Wolf, E., Klingenspor, M., Ivandic, B. T., Busch, D. H., Beckers, J. and Hrabe de Angelis, M.

PLoS ONE 2009. 4: e6054

Refining HPV 16 L1 purification from E. coli: reducing endotoxin contaminations and their impact on immunogenicity

Schadlich, L., Senger, T., Kirschning, C. J., Muller, M. and Gissmann, L.

Vaccine 2009. 27: 1511-1522

Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis

Siegemund, S., Hartl, A., von Buttlar, H., Dautel, F., Raue, R., Freudenberg, M. A., Fejer, G., Buttner, M., Kohler, G., Kirschning, C. J., Sparwasser, T. and Alber, G.

J Virol 2009. 83: 9411-9422

The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection

Steinberg, C., Eisenacher, K., Gross, O., Reindl, W., Schmitz, F., Ruland, J. and Krug, A.

Eur J Immunol 2009. 39: 1007-1018

Stem cell-like plasticity of naive and distinct memory CD8+ T cell subsets

Stemberger, C., Neuenhahn, M., Gebhardt, F. E., Schiemann, M., Buchholz, V. R. and Busch, D. H.

Semin Immunol 2009. 21: 62-68

The immunogenicity of CpG-antigen conjugates

Wagner, H.

Adv Drug Deliv Rev 2009. 61: 243-247

Endogenous Noxa Determines the Strong Proapoptotic Synergism of the BH3-Mimetic ABT-737 with Chemotherapeutic Agents in Human Melanoma Cells

Weber, A., Kirejczyk, Z., Potthoff, S., Ploner, C. and Hacker, G.

Transl Oncol 2009. 2: 73-83

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation

Werninghaus, K., Babiak, A., Gross, O., Holscher, C., Dietrich, H., Agger, E. M., Mages, J., Mocsai, A., Schoenen, H., Finger, K., Nimmerjahn, F., Brown, G. D., Kirschning, C., Heit, A., Andersen, P., Wagner, H., Ruland, J. and Lang, R.

J Exp Med 2009. 206: 89-97

Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity

Wilde, S., Sommermeyer, D., Frankenberger, B., Schiemann, M., Milosevic, S., Spranger, S., Pohla, H., Uckert, W., Busch, D. H. and Schendel, D. J.

Blood 2009. 114: 2131-2139