Publikationen Ag Buchholz

Mapping lymphocytes lineage decisions in vivo

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Selected Publications

Tsui, C., Kretschmer, L., Rapelius, S., Gabriel, S. S., Chisanga, D., Knöpper, K., Utzschneider, D. T., Nüssing, S., Liao, Y., Mason, T., Torres, S. V., Wilcox, S. A., Kanev, K., Jarosch, S., Leube, J., Nutt, S. L., Zehn, D., Parish, I. A., Kastenmüller, W., Shi, W., Buchholz, V. R. & Kallies, A. MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature 1–7 (2022). https://doi.org/10.1038/s41586-022-05105-1.

Kretschmer, L. & Buchholz, V. R. T cell memories of past divisions. Nat. Immunol. (2022). https://doi.org/10.1038/s41590-022-01193-3.

Grassmann, S., Sun, J. C. & Buchholz, V. R. Retrogenic Color-Barcoding for Fate Mapping of Single Innate Lymphocytes. Methods Mol. Biol. 2463, 117–127 (2022). https://doi.org/10.1007/978-1-0716-2160-8_9.

Plambeck, M., Kazeroonian, A., Loeffler, D., Kretschmer, L., Salinno, C., Schroeder, T., Busch, D. H., Flossdorf, M. & Buchholz, V. R. Heritable changes in division speed accompany the diversification of single T cell fate. Proceedings of the National Academy of Sciences 119, (2022). https://doi.org/10.1073/pnas.2116260119.

Flommersfeld, S., Böttcher, J. P., Ersching, J., Flossdorf, M., Meiser, P., Pachmayr, L. O., Leube, J., Hensel, I., Jarosch, S., Zhang, Q., Chaudhry, M. Z., Andrae, I., Schiemann, M., Busch, D. H., Cicin-Sain, L., Sun, J. C., Gasteiger, G., Victora, G. D., Höfer, T., Buchholz, V. R. & Grassmann, S. Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection. Immunity 54, 2288-2304.e7 (2021). https://doi.org/10.1016/j.immuni.2021.08.002.

Kretschmer, L., Busch, D. H. & Buchholz, V. R. A Single-Cell Perspective on Memory T-Cell Differentiation. Cold Spring Harb Perspect Biol (2021). https://doi.org/10.1101/cshperspect.a038067.

Grassmann, S., Mihatsch, L., Mir, J., Kazeroonian, A., Rahimi, R., Flommersfeld, S., Schober, K., Hensel, I., Leube, J., Pachmayr, L. O., Kretschmer, L., Zhang, Q., Jolly, A., Chaudhry, M. Z., Schiemann, M., Cicin-Sain, L., Höfer, T., Busch, D. H., Flossdorf, M. & Buchholz, V. R. Early emergence of T central memory precursors programs clonal dominance during chronic viral infection. Nat. Immunol. 170, 2022 (2020). https://doi.org/10.1007/978-1-0716-2160-8_9.

Kretschmer, L., Flossdorf, M., Mir, J., Cho, Y.-L., Plambeck, M., Treise, I., Toska, A., Heinzel, S., Schiemann, M., Busch, D. H. & Buchholz, V. R. Differential expansion of T central memory precursor and effector subsets is regulated by division speed. Nat Commun 11, 113 (2020). https://doi.org/10.1038/s41467-019-13788-w.

Buchholz, V. R. & Busch, D. H. Back to the Future: Effector Fate during T Cell Exhaustion. Immunity 51, 970–972 (2019). https://doi.org/10.1016/j.immuni.2019.11.007.

Grassmann, S., Pachmayr, L. O., Leube, J., Mihatsch, L., Andrae, I., Flommersfeld, S., Oduro, J., Cicin-Sain, L., Schiemann, M., Flossdorf, M. & Buchholz, V. R. Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection. Immunity 50, 1391-1400.e4 (2019). https://doi.org/10.1016/j.immuni.2019.04.015.

Buchholz, V. R. & Flossdorf, M. Single-Cell Resolution of T Cell Immune Responses. Adv. Immunol. 137, 1–41 (2018). https://doi.org/10.1016/bs.ai.2017.12.001(link is external).

Cho, Y.-L., Flossdorf, M., Kretschmer, L., Höfer, T., Busch, D. H. & Buchholz, V. R. TCR Signal Quality Modulates Fate Decisions of Single CD4(+) T Cells in a Probabilistic Manner. Cell Rep 20, 806–818 (2017). https://doi.org/10.1016/j.celrep.2017.07.005.

Buchholz, V. R., Schumacher, T. N. M. & Busch, D. H. T Cell Fate at the Single-Cell Level. Annu Rev Immunol 34, 65–92 (2016). https://doi.org/10.1146/annurev-immunol-032414-112014.

Graef, P., Buchholz, V. R., Stemberger, C., Flossdorf, M., Henkel, L., Schiemann, M., Drexler, I., Höfer, T., Riddell, S. R. & Busch, D. H. Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells. Immunity 41, 116–126 (2014). https://doi.org/10.1016/j.immuni.2014.05.018.

Buchholz, V. R., Flossdorf, M., Hensel, I., Kretschmer, L., Weissbrich, B., Gräf, P., Verschoor, A., Schiemann, M., Höfer, T. & Busch, D. H. Disparate individual fates compose robust CD8+ T cell immunity. Science 340, 630–635 (2013). https://doi.org/10.1126/science.1235454.

Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H.-W., Park, C. G., Steinman, R. M. & Nussenzweig, M. C. Differential antigen processing by dendritic cell subsets in vivo. Science 315, 107–111 (2007). https://doi.org/10.1126/science.1136080.