Carr A, Mateyka LM, Scheu SJC , Bici A, Paijmans J, Reijmers RM, Dieminger N, Dildebekova S, Hamed N, Wagner K, Busch DH und D’Ippolito E. 2024
Advances in preclinical TCR characterization: leveraging cell avidity to identify functional TCRs
Biol Chem 2024 Apr 29. PMID: 38666334 DOI: 10.1515/hsz-2023-0341
Svec M, Dötsch S, Warmuth L, Trebo M, Fräßle S, Riddell SR, Jäger U, D'Ippolito E, Busch DH. 2024
A chimeric antigen receptor-based cellular safeguard mechanism for selective in vivo depletion of engineered T cells.
Front Immunol. 2024 Jan 11;14:1268698. doi: 10.3389/fimmu.2023.1268698. eCollection 2023. PMID: 38274808
Jarosch S., Köhlen J., Ghimire S., Thiele Orberg E., Hammel M., Gaag D., Evert M., Janssen K.P., Hiergeist A., Gessner A., Weber D., Meedt E., Poeck H., D'Ippolito E., Holler E., Busch D.H. 2023
Multimodal immune cell phenotyping in GI biopsies reveals microbiome-related T cell modulations in human GvHD
Cell Rep Med. 2023 Jul 18;4(7): 101125.PMID: 37467715 PMCID: PMC10394271 DOI: 10.1016/j.xcrm.2023.101125
Dötsch S, Svec M, Schober K, Hammel M, Wanisch A , Gökmen F, Jarosch S, Warmuth L, Barton J, Cicin-Sain L, D'Ippolito E, Dirk H Busch D.H. 2023
Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression
Proc Natl Acad Sci U S A. 2023 Mar 7;120(10): e2200626120.PMID: 36853939 PMCID: PMC10013756 DOI: 10.1073/pnas.2200626120
Weber S, Kehl V, Erber J, Wagner K.I., Jetzlsperger AM, Burrell T, Schober K, Schommers P, Augustin M, Crowell CS, Gerhard M, Winter C, Moosmann A, Spinner CD, Protzer U, Hoffmann D, D'Ippolito E, Busch DH. 2022
CMV seropositivity is a potential novel risk factor for severe COVID-19 in non-geriatric patients.
PLoS One. 2022 May 25;17(5):e0268530. https://doi.org/10.1371/journal.pone.0268530. eCollection 2022.
Wagner KI, Mateyka LM, Jarosch S, Grass V, Weber S, Schober K, Hammel M, Burrell T, Kalali B, Poppert H, Beyer H, Schambeck S, Holdenrieder S. Strötges-Achatz A, Haselmann V, Neumaier MI, Erber J, Priller A, Yazici S, Roggendorf H, Odendahl M, Tonn T, Dick A, Witter K, Mijočević H, Protzer U, Knolle PA, Pichlmair A, Crowell CS, Gerhard M, D'Ippolito E, Busch DH. 2022
Recruitment of highly cytotoxic CD8 + T cell receptors in mild SARS-CoV-2 infection
Cell Rep., 2022 Jan 11;38(2):110214.https://doi.org/10.1016/j.celrep.2021.110214
Purcarea A, Jarosch S, Barton J, Grassmann S, Pachmayr L, D'Ippolito E, Hammel M, Hochholzer A, Wagner KI, van den Berg JH, Buchholz VR, Haanen JBAG, Busch DH, Schober K. 2022
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity.
Sci Immunol. 2022 Aug 12;7(74): PMID:35960818 DOI: 10.1126/sciimmunol.abm2077
Mateyka LM, Strobl PM, Jarosch S, Scheu SJC, Busch DH, D’Ippolito E. 2022
Gene Signatures of T-Cell Activation Can Serve as Predictors of Functionality for SARS-CoV-2-Specific T-Cell Receptors
Vaccines 2022, 10(10), 1617; https://doi.org/10.3390/vaccines10101617
Mateyka LM, Grass V, Pichlmair A, Busch DH, D'Ippolito E. 2022
SARS-CoV-2 CD8+ T cell killing assays using replicating viruses and transgenic antigens.
STAR Protoc. 2022 Aug 26;3(4):101699 PMID: 36152303 PMCID: PMC9411149 DOI:10.1016/j.xpro.2022.101699
Lückemeier P, Molter KL, Jarosch S, Huppertz P, Purcarea A, Effenberger MJP, Nauerth M, D'Ippolito E, Schober K, Busch DH. 2022
Global koff-rates of polyclonal T-cell populations merge subclonal avidities and predict functionality.
Eur J Immunol. 2022 Apr;52(4):582-596. DOI: 10.1002/eji.202149597 . Epub 2022 Feb 13. PMID: 35099805
Jarosch S, Köhlen J, Wagner S, D'Ippolito E, Busch DH. 2022
ChipCytometry for multiplexed detection of protein and mRNA markers on human FFPE tissue samples.
STAR Protoc. 2022 May 11;3(2):101374. PMID:35586313 PMCID: PMC9109191(link is external) DOI:10.1016/j.xpro.2022.101374
Schambeck SE, Crowell CS, Wagner KI, D'Ippolito E, Burrell T, Mijočević H, Protzer U, Busch DH, Gerhard M, Poppert H, Beyer H. 2021
Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
J Clin Med. 2021 Nov 12;10(22):5266. PMID: 34830550 PMCID: PMC8618742 DOI: 10.3390/jcm10225266
Jarosch S, Köhlen J, Sarker RSJ, Steiger K , Janssen KP ,Christians A , Hennig C , Holler E, D'Ippolito E, Busch DH. 2021
Multiplexed imaging and automated signal quantification in formalin-fixed paraffin-embedded tissues by ChipCytometry.
Cell Rep Methods., 2021 Oct 27;1(7):100104. https://doi.org/10.1016/j.crmeth.2021.100104
Fischer DS, Ansari M, Wagner KI, Jarosch S, Huang Y, Mayr CH, Strunz M, Lang NJ, D'Ippolito E, Hammel M, Mateyka L, Weber S, Wolff LS, Witter K, Fernandez IE, Leuschner G, Milger K, Frankenberger M, Nowak L, Heinig-Menhard K, Koch I, Stoleriu MG, Hilgendorff A, Behr J, Pichlmair A, Schubert B, Theis FJ, Busch DH, Schiller HB, Schober K.
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.
Nat Commun. 2021 Jul 26;12(1):4515. doi: 10.1038/s41467-021-24730-4.
D'Ippolito, E, Wagner KI, and Busch DH. 2020.
Needle in a Haystack: The Naive Repertoire as a Source of T Cell Receptors for AdoptiveTherapy with Engineered T Cells.
Int J Mol Sci. 21.
D'Ippolito, E., Schober K, Nauerth M, and Busch DH. 2019.
T cell engineering for adoptive T cell therapy: safety and receptor avidity.
Cancer Immunol Immunother. 68:1701-1712.